Thrust reversers having latching mechanisms and methods for manufacturing such thrust reversers are disclosed herein. An aircraft system in accordance with one embodiment includes a thrust reverser having a first inner panel and a second inner panel opposite the first inner panel. The first and second inner panels have an inner surface and an upper portion. The system further includes a catch projecting inwardly from the inner surface and the upper portion of the first inner panel, and a latch projecting inwardly from the inner surface and the upper portion of the second inner panel. The latch is positioned to selectively interlock with the catch to inhibit relative movement between the first and second inner panels.